University of Southern California

Yu Lab

USC Stem Cell

Selected Publications

2014

  • Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, Desai R, Zhu H, Comaills V, Zheng Z, Wittner BS, Stojanov P, Brachtel E, Sgroi D, Kapur R, Shioda T, Ting DT, Ramaswamy S, Getz G, Iafrate AJ, Benes C, Toner M, Maheswaran S, Haber DA. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science. 2014 July 11;345(6193):216-20. PMID: 25013076. [PubMed] [PDF]

2013

  • Ozkumur E, Shah AM, Ciciliano JC, Emmink BL, Miyamoto DT, Brachtel E, Yu M, Chen PI, Morgan B, Trautwein J, Kimura A, Sengupta S, Stott SL, Karabacak NM, Barber TA, Walsh JR, Smith K, Spuhler PS, Sullivan JP, Lee RJ, Ting DT, Luo X, Shaw AT, Bardia A, Sequist LV, Louis DN, Maheswaran S, Kapur R, Haber DA, Toner M. Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci. Transl. Med. 2013 Apr 3;5(179):179ra47. doi: 10.1126/scitranslmed.3005616. PMID: 23552373. [PubMed] [PDF]
  • Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, Concannon KF, Donaldson MC, Sequist LV, Brachtel E, Sgroi D, Baselga J, Ramaswamy S, Toner M, Haber DA, Maheswaran S. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science. 2013 Feb 1;339(6119): 580–584. doi: 10.1126/science.1228522. PMID: 23372014. [PubMed] [PDF]

2012

  • Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK. Expression profiling during mammary epithelial cell 3D morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2 mediated transformation. Mol. Cell Biol. 2012 Oct;32(19):3913–24. doi: 10.1128/MCB.00068-12. PMID: 22851698. [PubMed] [PDF]
  • Yu M, Ting DT, Stott SL, Wittner BS, Ozsolak F, Paul S, Ciciliano JC, Smas ME, Winokur D, Gilman AJ, Ulman MJ, Xega K, Contino G, Alagesan B, Brannigan BW, Milos PM, Ryan DP, Sequist LV, Bardeesy N, Ramaswamy S, Toner M, Maheswaran S, Haber DA. RNA sequencing of circulating tumor cells implicates non-canonical WNT signaling in pancreatic cancer metastasis. Nature. 2012 Jul 26;487(7408): 510–3. doi: 10.1038/nature11217. PMID: 22763454. [PubMed] [PDF]
  • Singh A, Sweeney MF, Yu M, Burger A, Greninger P, Benes C, Haber DA, Settleman J. TAK1 (MAP3K7) inhibition promotes apoptosis in KRAS-dependent colon cancers. Cell. 2012 Feb 17;148(4):639–50. doi: 10.1016/j.cell.2011.12.033. PMID: 22341439. [PubMed] [PDF]

2011

  • Yu M, Stott S, Toner M, Maheswaran S, Haber DA. Circulating tumor cells: approaches to isolation and characterization. J Cell Biol. 2011 Feb 7;192(3): 373–82. doi: 10.1083/jcb.201010021. PMID: 21300848. Review. [PubMed] [PDF]

2010

  • Stott SL, Hsu CH, Tsukrov DI, Yu M, Miyamoto DT, Waltman BA, Rothenberg SM, Shah AM, Smas ME, Korir GK, Floyd FP Jr, Gilman AJ, Lord JB, Winokur D, Springer S, Irimia D, Nagrath S, Sequist LV, Lee RJ, Isselbacher KJ, Maheswaran S, Haber DA, Toner M. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18392–7. doi: 10.1073/pnas.1012539107. PMID: 20930119. [PubMed] [PDF]
  • Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, Inserra EJ, Ulman M, Springer S, Nakamura Z, Moore AL, Tsukrov DI, Kempner ME, Dahl DM, Wu CL, Iafrate AJ, Smith MR, Tompkins RG, Sequist LV, Toner M, Haber DA, Maheswaran S. Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer. Sci. Transl. Med. 2010 Mar 31;2(25): ra23. doi: 10.1126/scitranslmed.3000403. PMID: 20424012. [PubMed] [PDF]

2009

  • Zhang J, Ji JY, Yu M, Overholtzer M, Smolen GA, Wang R, Brugge JS, Dyson NJ, Haber DA. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat. Cell Biol. 2009 Dec;11(12):1444–50. doi: 10.1038/ncb1993. PMID: 19935651. [PubMed] [PDF]
  • Yu M, Smolen GA, Zhang J, Wittner B, Schott BJ, Brachtel E, Ramaswamy S, Maheswaran S, Haber DA. A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression. Genes Dev. 2009 Aug 1;23(15):1737–42. doi: 10.1101/gad.1809309. PMID: 19651985. [PubMed] [PDF]